{"id":7466,"date":"2020-12-10T08:56:37","date_gmt":"2020-12-10T07:56:37","guid":{"rendered":"https:\/\/www.silfradent.com\/?page_id=7466"},"modified":"2020-12-10T08:56:37","modified_gmt":"2020-12-10T07:56:37","slug":"osteo-care","status":"publish","type":"page","link":"https:\/\/www.silfradent.com\/en\/osteo-care\/","title":{"rendered":"Osteo-Care"},"content":{"rendered":"
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Osseointegration improvement of dental prosthetic devices through autologous growth factors permeation of the implant surface<\/span><\/h2>
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Funding Source:
\n<\/strong>DM MiSE\u00a0 01 June 2016 \u2013 Horizon 2020 \u2013 PON 2014\/2020<\/p>\n

Project code:
\n<\/strong>F\/050370\/01\/X32<\/p>\n

Concession decree:
\n<\/strong>578 del 02\/03\/2018
\nStart date: 02\/11\/2019
\nEnd date: 01\/05\/2022<\/p>\n

Project Partner :<\/strong><\/p>\n

    \n
  • Silfradent s.r.l.<\/li>\n
  • Universit\u00e0 del Salento<\/li>\n
  • Andrea Francesco Palermo<\/li>\n<\/ul>\n

    Scientific manager:
    \n<\/strong>Prof.ssa Luisa Siculella<\/p>\n

    Places of performance :<\/strong><\/p>\n

      \n
    • Silfradent s.r.l. \u2013 Santa Sofia (FC) , via G. Di Vittorio, 35\/37 \u2013 Lecce, via A. Moro, 22<\/li>\n
    • Universit\u00e0 del Salento \u2013 Lecce, via Monteroni<\/li>\n
    • Andrea Francesco Palermo \u2013 Lecce, via A. Moro, 22<\/li>\n<\/ul>\n

      Total cost:<\/strong><\/p>\n

        \n
      • \u20ac 1.847.458,67 Industrial Research (RI)<\/li>\n
      • \u20ac 439.986,88 Experimental Development (SS)<\/li>\n<\/ul>\n

        General objective:
        \n<\/strong>The aim of this project is to improve the osseointegration characteristics of titanium dental implants. The research activity focuses on the adhesion of autologous growth factors, extracted with innovative techniques from the patient’s venous blood, on the surface of the device, thus obtaining a biologically active implant surface.\u00a0<\/strong><\/p>\n

        Objectives to be achieved:<\/strong><\/p>\n

          \n
        • OR1:Design of Medical Devices for the Treatment of Autologous Growth Factors – Plant Development: Materials-Shapes-Surfaces (RI) (SILFRADENT)<\/li>\n
        • OR2: Development of experimental prototypes of medical devices – Improvement of adhesion protocols \/ permeation of growth factors on the plant (SS) (SILFRADENT)<\/li>\n
        • OR3: Molecular and cytological characterization of enriched fractions in growth factors and implants in in vitro systems (RI) (UNISALENTO)<\/li>\n
        • OR4: Characterization of the effects of enriched fractions in growth factors and implants on neo-vascularization capacity in in-vitro angiogenesis models (RI) (UNISALENTO)<\/li>\n
        • OR5: Preliminary clinical evaluation (SS) (STUDIO DOTT. PALERMO)<\/li>\n
        • OR6: Statistical analysis of the data (RI) (UNISALENTO)<\/li>\n
        • OR7: Research analysis and possible protocols modification (SS) (SILFRADENT)<\/li>\n<\/ul>\n

          Expected results:
          \n<\/strong>One of the problems associated with titanium implants is their low wettability which requires immersion times in the biological matrix that are too long for clinical practice<\/p>\n

          The partners of this proposal intend to develop a protocol that makes possible the permeation process of the concentrate of growth factors on the titanium surface, using a dedicated implant vial, which allows the procedure to be carried out in a closed field, and a related device to the vial that allows incorporation in a few seconds.<\/p>\n

          This project aims to achieve a titanium dental implant, applicable to routine surgical practice, characterized by a biologically active surface rich in angiogenic growth factors and autologous stem cells able to improve the success of dental implant surgery and the duration of prostheses over time. To achieve this result it will be necessary to modify the implant design and the microstructure of the titanium surface to make it more available to the adhesion of the autologous biological matrix (CGF) and to reduce the time taken by the procedure with which the GFC adheres to the installation, by innovating the current process.<\/p>\n

          The achievement of this objective involves in vitro studies of the characteristics of the implant-CGF device to ensure that during the incorporation process the growth factors remain in the system and are released in situ, facilitating the healing process.<\/p>\n

          At a later stage, the validation of the device will be carried out through a clinical evaluation that involves the recruitment of volunteer subjects in which the device will be implanted with the biologically active surface realized in this project, comparing it to standard procedure.\u00a0The success rate of dental implants, the duration of osteointegration times and the duration of the implants applied will be evaluated.<\/p>\n

          The repercussions of the research activity are not limited to the titanium dental implant but range in different surgical practices where there is the need to accelerate the healing processes.<\/p>\n[\/vc_column_text]

          <\/div>
          <\/span><\/div>
          <\/div>[vc_column_text]Electron microscopy image of the interface device on which the CGF fraction was deposited<\/em>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column width=”1\/4″]
          <\/span><\/div>
          <\/div>[vc_column_text]Figure 9 – APAG TWIN prototype<\/em>[\/vc_column_text][\/vc_column][vc_column width=”1\/4″]
          <\/span><\/div>[vc_column_text]Figure 10 \u2013 Inner view of heating elements<\/em>[\/vc_column_text][\/vc_column][vc_column width=”1\/4″]
          <\/span><\/div>[vc_column_text]Figure 11 \u2013 Power card view<\/em>[\/vc_column_text][\/vc_column][vc_column width=”1\/4″]
          <\/span><\/div>[vc_column_text]Figure 12 \u2013 Front view heating elements.<\/em>[\/vc_column_text][\/vc_column][\/vc_row]\n<\/div>","protected":false},"excerpt":{"rendered":"

          [vc_row][vc_column][vc_column_text] Funding Source: DM MiSE\u00a0 01 June 2016 \u2013 Horizon 2020 \u2013 PON 2014\/2020 Project code: F\/050370\/01\/X32 Concession decree: 578 del 02\/03\/2018 Start date: 02\/11\/2019 End date: 01\/05\/2022 Project Partner : Silfradent s.r.l. Universit\u00e0 del Salento Andrea Francesco Palermo Scientific…<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-7466","page","type-page","status-publish","hentry","entry","no-media"],"yoast_head":"\nOsteo-Care | Silfradent<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.silfradent.com\/en\/osteo-care\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Osteo-Care | Silfradent\" \/>\n<meta property=\"og:description\" content=\"[vc_row][vc_column][vc_column_text] Funding Source: DM MiSE\u00a0 01 June 2016 \u2013 Horizon 2020 \u2013 PON 2014\/2020 Project code: F\/050370\/01\/X32 Concession decree: 578 del 02\/03\/2018 Start date: 02\/11\/2019 End date: 01\/05\/2022 Project Partner : Silfradent s.r.l. 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